WO2009113795A3 - Vector and method for expressing avian influenza virus neuraminidase n1 in e. coli, method of using the vector, and neuraminidase inhibitors - Google Patents
Vector and method for expressing avian influenza virus neuraminidase n1 in e. coli, method of using the vector, and neuraminidase inhibitors Download PDFInfo
- Publication number
- WO2009113795A3 WO2009113795A3 PCT/KR2009/001184 KR2009001184W WO2009113795A3 WO 2009113795 A3 WO2009113795 A3 WO 2009113795A3 KR 2009001184 W KR2009001184 W KR 2009001184W WO 2009113795 A3 WO2009113795 A3 WO 2009113795A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vector
- neuraminidase
- coli
- avian influenza
- influenza virus
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Abstract
Disclosed are a vector and method for expressing neuraminidase Nl of avian influenza (AI) virus in E. coli, a method of using the vector to screen an inhibitor of neuraminidase Nl, and a novel neuraminidase Nl inhibitor screened out by the method.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2008-0021970 | 2008-03-10 | ||
KR1020080021970A KR20090096890A (en) | 2008-03-10 | 2008-03-10 | Vectors and processes for expression of neuraminidase n1 of avian influenza virus in e. coli, methods of using the same, and agents for inhibiting activities of the neuraminidase |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009113795A2 WO2009113795A2 (en) | 2009-09-17 |
WO2009113795A3 true WO2009113795A3 (en) | 2010-02-25 |
Family
ID=41065661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2009/001184 WO2009113795A2 (en) | 2008-03-10 | 2009-03-10 | Vector and method for expressing avian influenza virus neuraminidase n1 in e. coli, method of using the vector, and neuraminidase inhibitors |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR20090096890A (en) |
WO (1) | WO2009113795A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8575197B2 (en) | 2008-09-25 | 2013-11-05 | Shionogi & Co., Ltd. | Pyrolinone derivative and pharmaceutical composition comprising the same |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102822343B (en) * | 2009-12-28 | 2017-10-20 | 赛诺菲疫苗技术公司 | The production of heterologous polypeptide in microalgae, the extracellular body of microalgae, composition and its production and use |
CN103951602B (en) * | 2014-03-19 | 2016-06-15 | 河南理工大学 | There is the synthetic method of pyrroles's thiosemicarbazones copper of anti-tumor activity, nickel complex |
US20180303807A1 (en) * | 2015-10-01 | 2018-10-25 | John Katzenellenbogen | Androgen receptor ligands |
CN105646495A (en) * | 2016-01-06 | 2016-06-08 | 中山大学 | Pyrrolo[2,3-b]pyrazine derivatives, and preparation method and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4537769A (en) * | 1982-04-06 | 1985-08-27 | American Cyanamid Company | Stabilization of influenza virus vaccine |
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2008
- 2008-03-10 KR KR1020080021970A patent/KR20090096890A/en active Application Filing
-
2009
- 2009-03-10 WO PCT/KR2009/001184 patent/WO2009113795A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4537769A (en) * | 1982-04-06 | 1985-08-27 | American Cyanamid Company | Stabilization of influenza virus vaccine |
Non-Patent Citations (2)
Title |
---|
QI-SHI DU ET AL.: "Analogue inhibitors by modifying oseltamivir based on the crystal neuraminidase structure for treating drug-resistant H5N1 virus", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 362, no. 2, 13 August 2007 (2007-08-13), pages 525 - 531 * |
SONTANA SIRITANTIKORN ET AL.: "Specific antibody response of mice after immunization with COS-7 cell derived avian influenza virus(H5Nl) recombinant proteins", JOURNAL OF IMMUNE BASED THERAPIES AND VACCINES, vol. 5, no. 1, 3 October 2007 (2007-10-03), pages 1 - 5 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8575197B2 (en) | 2008-09-25 | 2013-11-05 | Shionogi & Co., Ltd. | Pyrolinone derivative and pharmaceutical composition comprising the same |
Also Published As
Publication number | Publication date |
---|---|
KR20090096890A (en) | 2009-09-15 |
WO2009113795A2 (en) | 2009-09-17 |
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