CN102671089B - Suppository for treating mycotic vaginitis - Google Patents

Suppository for treating mycotic vaginitis Download PDF

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Publication number
CN102671089B
CN102671089B CN201210182861.7A CN201210182861A CN102671089B CN 102671089 B CN102671089 B CN 102671089B CN 201210182861 A CN201210182861 A CN 201210182861A CN 102671089 B CN102671089 B CN 102671089B
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grams
suppository
herba
volatile oil
thick paste
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CN201210182861.7A
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CN102671089A (en
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杨秋兰
侯峰
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Abstract

Provided is a suppository for treating mycotic vaginitis. A traditional Chinese medicine is that the suppository comprises 50g of densefruit pittany root-bark, 30g of dandelion, 30g of dahurian patrinia herb, 30g of phellodendron amurense, 30g of sophora flavescens, 30g of vervain, 15g of stemona, 30g of common cnidium fruit, 15g of wild pepper, 20g of poria cocos, 20g of sevenlobed yam rhizome and 15g of longhairy antenoron herb. A process comprises utilizing ethanol of 80% to perform extraction from the sophora flavescens, the vervain and the stemona, and performing concentration to form thick paste for reserve; adding water to the wild pepper, soaking for 1h, and utilizing a volatile oil extractor to exact volatile oil for reserve; adding the densefruit pittany root-bark, the dandelion, the dahurian patrinia herb, the phellodendron amurense, the common cnidium fruit, the sevenlobed yam rhizome, the longhairy antenoron herb and the poria cocos which are soaked for 1h to dregs of the sophora flavescens, the vervain, the stemona and the wild pepper, adding water, performing decoction, carrying out extraction twice, and performing concentration to form thick paste for reserve; enabling a proper amount of semisynthetic fatty glyceride and tween-80 to undergo water bath melting, then adding the thick paste, and evenly mixing; and adding the extracted volatile oil when the mixture is cooled to about 50 DEG C, evenly mixing, cooling to solidification, scraping overflowed suppository blocks, performing split charging into sterilized plastic casings, and obtaining the suppository.

Description

A kind of suppository for the treatment of colpitis mycotica
Technical field:
The invention belongs to technical field of Chinese medicines, particularly a kind of suppository for the treatment of colpitis mycotica.
Background technology:
Colpitis mycotica is the common disease of gynecological, and main manifestations is leucorrhoea grow in quantity, is curdy, and vagina and vulva is very itched unbearably, pudendum is usually rubescent around, edema, and vaginal smear microscopy has candidiasis spore.Primary disease belongs to the category of Traditional Chinese Medicine " pudendal pruritus ", " leukorrheal diseases ".Theory of Chinese medical science thinks that it is due to damp-heat accumulation in body, and adds outer being subject to due to the evil infection of poison.Damp and hot is endogenous cause of ill, and malicious heresy is exopathogenic factor, and endogenous cause of ill, exopathogenic factor interact and make the state of an illness touching.With the passing of time damp and hot heresy must impairment of YIN, occurs the syndrome of the simulataneous insufficiency and excessive of cloudy wound, damp and hot retardance.During treatment, take heat clearing and damp drying, dispel the treatment policy of evil poison.With the therapy of Traditional Chinese Medicine inner disease outer treat, in reaching except damp and hot, eliminating evil poison, thoroughly cure the cloudy scorching effect of mycotic.
Summary of the invention:
The invention provides a kind of suppository for the treatment of colpitis mycotica, the Chinese medicine formula of the suppository of this treatment colpitis mycotica is: 15 grams of 50 grams of Cortex Dictamni, 30 grams of Herba Taraxacis, 30 grams of Herba Patriniae, 30 grams of Cortex Phellodendris, 30 grams of Radix Sophorae Flavescentiss, 30 grams of Herba Verbenae, 15 grams of the Radixs Stemonae, 30 grams of Fructus Cnidiis, 15 grams, Pericarpium Zanthoxyli, 20 grams of 20 grams of, Rhizoma Dioscoreae Septemlobae of Poria and Herba Lysimachiaes.
Its processing technology: (1) gets 80% ethanol extraction 2 times for Radix Sophorae Flavescentis, Herba Verbenae, the Radix Stemonae, each 1 hour, merge alcohol extract, decompression recycling ethanol, is concentrated into thick paste, standby; (2) Pericarpium Zanthoxyli is soaked 1 hour, with volatile oil extractor, extracts volatile oil, standby; (3) Radix Sophorae Flavescentis, Herba Verbenae, the Radix Stemonae, Pericarpium Zanthoxyli medicinal residues are added to the Cortex Dictamni, Herba Taraxaci, Herba Patriniae, Cortex Phellodendri, Fructus Cnidii, Rhizoma Dioscoreae Septemlobae, Herba Lysimachiae, the Poria that soak 1 hour and decoct with water extraction 2 times, each 1 hour, collecting decoction boils liquid, is concentrated into thick paste, standby; (4) get after appropriate semi-synthetic fatty acid glyceride and tween 80 are put water-bath melting and again the thick paste making in (1) step neutralization (3) step is added, stir; To be cooledly to 50 ℃ of left and right, add the volatile oil extracting in (2) step to stir evenly, inject and be coated with in the bolt mould of lubricant, be cooled to and solidify, scrape off and overflow bolt piece, after taking-up, under uviol lamp, irradiate 30 minutes, be sub-packed in the plastic housing of sterilization and get final product.
Method for making explanation: the antiinflammatory action of pinanol extract is better than water extract, and alcohol extract is longer than the analgesic activity persistent period of water extract, thus first alcohol extraction, rear water extraction; Pericarpium Zanthoxyli contains volatile oil, with volatile oil extractor, extracts; Add twen-80, can increase drug-eluting speed, and increased the toughness of suppository, reduce fragility.
The mechanism of action: the vaginitis traditional Chinese medical science thinks that damp and hot foul heresy damage vessels of the uterus, punching appoint the impaired so that dai channel of QI and blood to fail to keep an appointment, and conception vessel is solid.Fructus Cnidii, Cortex Dictamni, Fructus Cnidii, Cortex Phellodendri anti-inflammation and sterilization, dampness removing, Herba Taraxaci, Herba Patriniae, Herba Verbenae heat-clearing and toxic substances removing, Radix Sophorae Flavescentis, Cortex Dictamni, the Radix Stemonae, the antibacterial parasite killing of Pericarpium Zanthoxyli dampness removing to stop itchin, wind dispelling is antipruritic.Poria, Rhizoma Dioscoreae Septemlobae and the heat clearing away of Herba Lysimachiae dampness removing, dispel turbid; All medicines share the effect of total heat-clearing and toxic substances removing, expelling wind and removing dampness, killing parasites for relieving itching, anti-inflammatory analgetic.Because medicine destroys without gastrointestinal, directly act on mucocutaneously, and enter blood by transdermal mucosa absorption, therefore external is shown in that than oral medicine curative effect is fast, comfortable, without any side effects advantage, can not increase burden of liver yet, makes suppository and facilitates patient to use.
The specific embodiment:
Treat a suppository for colpitis mycotica, the Chinese medicine formula of the suppository of this treatment colpitis mycotica is: 15 grams of 50 grams of Cortex Dictamni, 30 grams of Herba Taraxacis, 30 grams of Herba Patriniae, 30 grams of Cortex Phellodendris, 30 grams of Radix Sophorae Flavescentiss, 30 grams of Herba Verbenae, 15 grams of the Radixs Stemonae, 30 grams of Fructus Cnidiis, 15 grams, Pericarpium Zanthoxyli, 20 grams of 20 grams of, Rhizoma Dioscoreae Septemlobae of Poria and Herba Lysimachiaes.Its processing technology: (1) gets 80% ethanol extraction 2 times for Radix Sophorae Flavescentis, Herba Verbenae, the Radix Stemonae, each 1 hour, merge alcohol extract, decompression recycling ethanol, is concentrated into thick paste, standby; (2) Pericarpium Zanthoxyli is soaked 1 hour, with volatile oil extractor, extracts volatile oil, standby; (3) Radix Sophorae Flavescentis, Herba Verbenae, the Radix Stemonae, Pericarpium Zanthoxyli medicinal residues are added to the Cortex Dictamni, Herba Taraxaci, Herba Patriniae, Cortex Phellodendri, Fructus Cnidii, Rhizoma Dioscoreae Septemlobae, Herba Lysimachiae, the Poria that soak 1 hour and decoct with water extraction 2 times, each 1 hour, collecting decoction boils liquid, is concentrated into thick paste, standby; (4) get after appropriate semi-synthetic fatty acid glyceride and tween 80 are put water-bath melting and again the thick paste making in (1) step neutralization (3) step is added, stir; To be cooledly to 50 ℃ of left and right, add the volatile oil extracting in (2) step to stir evenly, inject and be coated with in the bolt mould of lubricant, be cooled to and solidify, scrape off and overflow bolt piece, after taking-up, under uviol lamp, irradiate 30 minutes, be sub-packed in the plastic housing of sterilization and get final product.
Clinical verification:
Vagina depths is used, and first uses warm water washing pudendum before use, wipes away the dry rear finger of putting on plastic fingertip of using stype is filled in to vagina, and 1 time~2 times/day, after medication, 2 days~6 days symptoms can be alleviated, and within 2 weeks, are 1 course for the treatment of, can repeat if desired.
By this side's treatment colpitis mycotica person 80 examples, medication 3~15 days, cured person 70 examples; Effective person's 8 examples; Nonresponder's 2 examples, total effective rate 97.2%.
1, in certain, 29 years old, patient's profuse leukorrhea was curdy, and pudendum and vagina are very itched unbearably; Gynecologial examination: red and swollen, the congested adularescent sheet film of vaginal mucosa severe adheres to, stripping easily from, can expose rotten to the corn substrate, picture microscopy, having candidiasis spore is fungal infection.Once treated 2 months without obviously alleviating, and with this side vagina medicinal every day 1~2 time, shared and obviously alleviate for 6 times, and continued to use and consolidate a few days, and rechecked and fully recover.
2, Wang, female, 24 years old, main manifestations was dysurea, urgent micturition, frequent micturition, pudendum and pruritus of vagina, sexual intercourse pain, leucorrhea is many, gynecologial examination: pudendum is red and swollen, and pudendum and vagina have volume white secretions, are bean curd slag specimen.Microscopy: mycete ++.Treatment: with wearing fingerstall after basin cleaning pudendum, suppository is sent into vagina before sleeping, medication is leucorrhea minimizing after 2 days, and gargalesthesia alleviates, and treats altogether recovery from illness in 5 days.
3, Lee, 36 years old, pudendum and vagina were very itched unbearably, and pudendum and vagina have volume white secretions, microscopy: mycete+, treatment: with wearing fingerstall after basin cleaning pudendum, suppository is sent into vagina before sleeping, medication is leucorrhea minimizing after 1 day, and gargalesthesia alleviates, and treats altogether recovery from illness in 3 days.
4, Zhang, 32 years old, gynecologial examination: red and swollen, the congested adularescent sheet film of vaginal mucosa severe adheres to, pudendum and vagina have volume white secretions, picture microscopy, is fungal infection, with this side's vagina medicinal every day 1~2 time, share and obviously alleviate for 5 times, continue to use and consolidate a few days, recheck recovery from illness.
5, Lee, female, 25 years old, anemia of pregnant woman, main manifestations is leucorrhoea grow in quantity, vagina and pudendal pruritus, edema, vaginal secretions is thickness bean curd slag specimen, easily peels off, and chemical examination detects as fungal infection, treat to after sodium bicarbonate solution rinsing vulva and vagina with 2~3%, with this suppository, fill in vagina, every day 2 times, after 2 days, symptom obviously alleviates, and leucorrhea reduces, and pruritus alleviates, continue to strengthen treatment 3 days, it is normal that further consultation microscopy vaginal secretions is recovered.

Claims (2)

1. a suppository for the treatment of colpitis mycotica, is characterized in that: the Chinese medicine formula of the suppository of this treatment colpitis mycotica is: 15 grams of 50 grams of Cortex Dictamni, 30 grams of Herba Taraxacis, 30 grams of Herba Patriniae, 30 grams of Cortex Phellodendris, 30 grams of Radix Sophorae Flavescentiss, 30 grams of Herba Verbenae, 15 grams of the Radixs Stemonae, 30 grams of Fructus Cnidiis, 15 grams, Pericarpium Zanthoxyli, 20 grams, Poria, 20 grams of Rhizoma Dioscoreae Septemlobae and Herba Lysimachiaes.
2. a kind of suppository for the treatment of colpitis mycotica according to claim 1, is characterized in that: (1) gets 80% ethanol extraction 2 times for Radix Sophorae Flavescentis, Herba Verbenae, the Radix Stemonae, each 1 hour, merge alcohol extract, and decompression recycling ethanol, is concentrated into thick paste, standby; (2) Pericarpium Zanthoxyli is soaked 1 hour, with volatile oil extractor, extracts volatile oil, standby; (3) Radix Sophorae Flavescentis, Herba Verbenae, the Radix Stemonae, Pericarpium Zanthoxyli medicinal residues are added to the Cortex Dictamni, Herba Taraxaci, Herba Patriniae, Cortex Phellodendri, Fructus Cnidii, Rhizoma Dioscoreae Septemlobae, Herba Lysimachiae, the Poria that soak 1 hour and decoct with water extraction 2 times, each 1 hour, collecting decoction boils liquid, is concentrated into thick paste, standby; (4) get after appropriate semi-synthetic fatty acid glyceride and tween 80 are put water-bath melting and again the thick paste making in (1) step neutralization (3) step is added, stir; To be cooledly to 50 ℃ of left and right, add the volatile oil extracting in (2) step to stir evenly, inject and be coated with in the bolt mould of lubricant, be cooled to and solidify, scrape off and overflow bolt piece, after taking-up, under uviol lamp, irradiate 30 minutes, be sub-packed in the plastic housing of sterilization and get final product.
CN201210182861.7A 2012-05-31 2012-05-31 Suppository for treating mycotic vaginitis Expired - Fee Related CN102671089B (en)

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103977291A (en) * 2014-05-30 2014-08-13 桂林恒保健康用品有限公司 Traditional Chinese medicine composition for treating colpitis mycotica
CN104815224A (en) * 2015-05-27 2015-08-05 薛建芳 Traditional Chinese medicine for treating accumulated dampness-toxicity type colpitis mycotica and preparation method thereof
CN109223705A (en) * 2018-10-09 2019-01-18 杨世林 Matrine rectal suppository and its preparation method and application

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1092977A (en) * 1993-12-01 1994-10-05 董兴武 Jietai lotion and preparation technology thereof
CN1895511A (en) * 2005-07-15 2007-01-17 张庆华 Colpitis medicine and its preparation
CN101559188A (en) * 2009-05-18 2009-10-21 甘肃益尔药业股份有限公司 Traditional Chinese medicine compound preparation used for treating colpitis and tinea manus and pedis and preparation method thereof
CN102008670A (en) * 2010-10-29 2011-04-13 荣成市新技术应用研究所 Gynaecological external washing drug
CN102145111A (en) * 2011-04-18 2011-08-10 李佃场 Traditional Chinese medicine composition for treating colpitis mycotica and preparation method of traditional Chinese medicine composition

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1092977A (en) * 1993-12-01 1994-10-05 董兴武 Jietai lotion and preparation technology thereof
CN1895511A (en) * 2005-07-15 2007-01-17 张庆华 Colpitis medicine and its preparation
CN101559188A (en) * 2009-05-18 2009-10-21 甘肃益尔药业股份有限公司 Traditional Chinese medicine compound preparation used for treating colpitis and tinea manus and pedis and preparation method thereof
CN102008670A (en) * 2010-10-29 2011-04-13 荣成市新技术应用研究所 Gynaecological external washing drug
CN102145111A (en) * 2011-04-18 2011-08-10 李佃场 Traditional Chinese medicine composition for treating colpitis mycotica and preparation method of traditional Chinese medicine composition

Non-Patent Citations (2)

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Title
《中药内服外洗治疗霉菌性阴道炎66例》;朱慧萍;《实用中医药杂志》;20070228;第23卷(第2期);84 *
朱慧萍.《中药内服外洗治疗霉菌性阴道炎66例》.《实用中医药杂志》.2007,第23卷(第2期),84.

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